1,2-di-tert-butyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate
BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
CAS: 166410-05-5
Molecular Formula: C14H23NO5
1,2-di-tert-butyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate - Names and Identifiers
| Name | BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER |
| Synonyms | K204 Boc-4-OXO-Pro-OtBu BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER N-BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER 1-(tert-butoxycarbonyl)-4-oxo-L-proline N-T-BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER ditert-butyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate di-tert-butyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate (2S) tert-butyl N-(tert-butoxycabonyl)-4-oxoprolinate 1,2-di-tert-butyl (2S)-4-oxopyrrolidine-1,2- dicarboxylate |
| CAS | 166410-05-5 |
| InChI | InChI=1/C10H15NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h7H,4-5H2,1-3H3,(H,13,14)/t7-/m0/s1 |
1,2-di-tert-butyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate - Physico-chemical Properties
| Molecular Formula | C14H23NO5 |
| Molar Mass | 285.34 |
| Density | 1.138±0.06 g/cm3(Predicted) |
| Melting Point | 64-67°C |
| Boling Point | 366.7±42.0 °C(Predicted) |
| Flash Point | 190.123°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | -3.86±0.40(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.516 |
1,2-di-tert-butyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate - Introduction
BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER is an organic compound with the chemical formula C13H21NO6. It is a white solid, stable at room temperature. The following describes its nature, use, preparation and safety information:
Nature:
BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER has low solubility and is soluble in organic solvents such as dimethylformamide (DMF) and dichloromethane. It is a stable compound that does not easily decompose at room temperature. Its molecular structure contains oxygen (-COOR) and Boc protecting groups, which make it have certain chemical activity in organic synthesis.
Use:
BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER is often used as an intermediate in organic synthesis. Because its structure contains amino acid groups, it is often used in the synthesis of peptide compounds. By controlling the reaction conditions, the Boc protecting group can be removed to obtain a free amino acid, which can be used to synthesize natural proteins, drugs and other biologically active molecules.
Method:
There are many methods for preparing BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER. One common method is to acidify proline with tert-butyl alcohol to generate proline tert-butyl ESTER, and then esterify it with acetic anhydride to generate BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER.
Safety Information:
BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER is a relatively safe compound under normal use conditions. However, it is subject to some regular laboratory safety measures. Wear suitable personal protective equipment such as laboratory gloves and goggles when handling the compound. At the same time, it should be operated under well-ventilated laboratory conditions to avoid its potential impact on the human body and the environment.
Nature:
BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER has low solubility and is soluble in organic solvents such as dimethylformamide (DMF) and dichloromethane. It is a stable compound that does not easily decompose at room temperature. Its molecular structure contains oxygen (-COOR) and Boc protecting groups, which make it have certain chemical activity in organic synthesis.
Use:
BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER is often used as an intermediate in organic synthesis. Because its structure contains amino acid groups, it is often used in the synthesis of peptide compounds. By controlling the reaction conditions, the Boc protecting group can be removed to obtain a free amino acid, which can be used to synthesize natural proteins, drugs and other biologically active molecules.
Method:
There are many methods for preparing BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER. One common method is to acidify proline with tert-butyl alcohol to generate proline tert-butyl ESTER, and then esterify it with acetic anhydride to generate BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER.
Safety Information:
BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER is a relatively safe compound under normal use conditions. However, it is subject to some regular laboratory safety measures. Wear suitable personal protective equipment such as laboratory gloves and goggles when handling the compound. At the same time, it should be operated under well-ventilated laboratory conditions to avoid its potential impact on the human body and the environment.
Last Update：2024-04-09 21:11:58
